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Isotretinoin (Accutane) is used to treat severe recalcitrant nodular acne (a certain type of severe acne) that has not been helped by other treatments, such as antibiotics. Isotretinoin is in a class of medications called retinoids. It works by slowing the production of certain natural substances that can cause pimples to form.

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Taking isotretinoin…
Isotretinoin comes as a capsule to take by mouth.
Isotretinoin is usually taken twice a day with meals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take isotretinoin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with a full glass of liquid. Do not chew or suck on the capsules.
Your doctor will probably start you on an average dose of isotretinoin and increase or decrease your dose depending on how well you respond to the medication and the side effects you experience. Follow these directions carefully and ask your doctor or pharmacist if you are not sure how much isotretinoin you should take.

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It may take several weeks or longer for you to feel the full benefit of isotretinoin. Your acne may get worse during the beginning of your treatment with isotretinoin. This is normal and does not mean that the medication is not working.
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Isotretinoin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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- red, cracked, and sore lips
- dry skin, eyes, mouth, or nose
- nosebleeds
- changes in skin color
- peeling skin, especially on the palms and soles
- changes in the nails
- slowed healing of cuts or sores
- bleeding or swollen gums
- hair loss or unwanted hair growth
- sweating
- flushing
- voice changes
- tiredness
- cold symptoms

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Some side effects can be serious:
• headache
• blurred vision
• dizziness
• upset stomach
• vomiting
• seizures
• slow or difficult speech
• weakness or numbness of one part or side of the body
• stomach pain
• chest pain
• difficulty swallowing or pain when swallowing
• new or worsening heartburn
• diarrhea
• rectal bleeding
• yellowing of the skin or eyes
• dark colored urine
• back, bone, joint or muscle pain
• muscle weakness
• difficulty hearing
• ringing in the ears
• vision problems

!!!Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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