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Metronidazole (Flagul) - is an antibiotic effective against anaerobic bacteria and certain parasites. Anaerobic bacteria are single–celled, living organisms that thrive in environments in which there is little oxygen (anaerobic environments) and can cause disease in the abdomen (bacterial peritonitis), liver (liver abscess), and pelvis (abscess of the ovaries and the Fallopian tubes)
Metronidazole is used to treat parasitic infections including Giardia infections of the small intestine, amebic liver abscess and amebic dysentery (infection of the colon causing bloody diarrhea), trichomonas vaginal infections, and carriers of trichomonas (both sexual partners) who do not have symptoms of infection.

Metronidazole is also used alone or in combination with other antibiotics in treating abscesses in the liver, pelvis, abdomen and brain caused by susceptible anaerobic bacteria.

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Dosing Flagul:
- Metronidazole may be taken orally with or without food.
- In the hospital, metronidazole can be administered intravenously to treat serious infections. The liver is primarily responsible for eliminating metronidazole from the body, and doses may need to be reduced in patients with liver disease and abnormal liver function.
- Take each dose with a full glass of water.
- Use this medicine exactly as directed by your doctor. If you do not understand the instructions, ask your pharmacist, nurse, or doctor to explain you.

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Side effects:
Metronidazole is a valuable antibiotic and is generally well tolerated with appropriate use. Minor side effects include: nausea, headaches, loss of appetite, a metallic taste, and rarely a rash.
Serious side effects of metronidazole are rare. Among them - seizures and damage of nerves resulting in numbness and tingling of extremities (peripheral neuropathy). Metronidazole should be stopped if these symptoms appear.
Drug interaction:
- Alcohol should be avoided because metronidazole and alcohol together can cause severe nausea, vomiting, cramps, flushing, and headache.
- Metronidazole can increase the blood thinning effects of warfarin (Coumadin) and increase the risk of bleeding probably by reducing the break down of warfarin.
- Metronidazole should not be combined with amprenavir for treating human immunodeficiency disease (infection with HIV) because amprenavir contains propylene glycol. Metronidazole blocks the breakdown of propylene glycol in the liver leading to accumulation of propylene glycol in blood. Accumulation of propylene glycol could cause seizures, increased heart rate, and lead to kidney failure.
- Metronidazole increases the blood levels of carbamazepine, lithium and cyclosporine though unknown mechanisms. Serious reactions may occur if these drugs are taken with metronidazole.

!!!Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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